CHEM6353 is a graduate-level Physical Organic Chemistry course, and a logical extension of another mechanistic course, CHEM6311. The course applies the principles of thermodynamic and kinetic analysis onto the problems in modern organic chemistry. The first third of the course covers the much-debated concept of aromaticity and its application to the analysis of aromatic substitution and pericyclic reactions. Following discussion of organic polymers, electronic materials, and photochemistry, the final third of the course deals with the crucial role physical organic chemistry plays in the studies of molecular recognition, supramolecular chemistry, and dynamic covalent chemistry that occurs under thermodynamic control. Students also gain experience in 3D modelling and 3D printing.